Custom Peptides
Cayman Chemical CalcInurIn SubstrATtrIflu 10mg
A synthetic peptide substrate; can be used as a substrate to quantify calcineurin activity
Cayman Chemical JWH 073 2mthylnapthyl nal 10mg
Differs structurally from JWH 073 by having a methyl group added at the 2 position of the naphthyl moiety; intended for forensic and research purposes
Cayman Chemical 6dIazo5oxoLnorLeucIn 10mg
A glutamine analog that inhibits glutaminases (Ki = 6 µM) and other glutamine-utilizing enzymes, including cytidine triphosphate synthase
Cayman Chemical 5-fluoro CUMYL-PICA 10mg
An analog of CUMYL-PICA characterized by the addition of an alkyl-terminal fluorine atom; intended for forensic and research applications
Cayman Chemical 2EthylethcathInonhydrochl 10mg
A substituted cathinone with potential for abuse; intended for forensic and research applications
Cayman Chemical TetrahydrocurcumIn 10mg
A metabolite of curcumin with diverse biological activities; scavenges DPPH radicals in a cell-free assay (EC50 = 16.8 μM); inhibits LPS-induced increases in iNOS and COX-2 expression in RAW 264.7 cells at 50 µM; inhibits LPS-induced increases in TNF-α release at 100 µM; inhibits LPS-induced increases in NO production and IL-6 levels in a concentration-dependent manner; reduces carrageenan-induced paw edema in rats (ED50 = 20 mg/kg); reduces the formation of neocapillaries and decreases microvascular density as well as VEGF, VEGFR2, and HIF-1α expression in a CaSki cervical cancer nude mouse xenograft model at 100, 300, and 500 mg/kg
Cayman Chemical ncrostatIn-2 10mg
A potent inhibitor of necroptosis (EC50 = 50 nM); 4-fold more active than the (S)-enantiomer (EC50 = 230 nM)
Cayman Chemical 12-ProstaglndIn D2 10mg
PGD2 is one of the five primary enzymatic prostaglandins derived directly from PGH2. PGD2 is produced abundantly in the CSF by the lipocalin-type PGD synthase, and in the periphery by myeloid cells including mast cells and basophils by a second, hematopoietic-type PGD synthase. PGD2 is chemically unstable, and its use and analysis is complicated by its short in vivo half-life. .DELTA.12-PGD2 is one of the initial chemical decomposition products of PGD2. .DELTA.12-PGD2 is an intermediate in the pathway leading to .DELTA.12-PGJ2, which is a cyclopentenone prostaglandin with antimitotic and carcinogenic activities.{870,334} The metabolism of .DELTA.12-PGD2 involves addition of thiol nucleophiles, as is the case with the majority of cyclopentenone prostaglandins.{7193}
Cayman Chemical EpothIlon B 10mg
A macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis; induces mitotic arrest at nanomolar IC50 values in cell lines from ovarian, breast, lung, colon, prostate, and squamous cancer
Cayman Chemical 14deoxy11 12dIdehydro ndr 10mg
A noncytotoxic analog of the natural diterpenoid that possesses anti-inflammatory, antiallergenic, immuno-stimulatory, antiviral, antioxidant, hepatoprotective, and cardiovascular activities
Cayman Chemical Cardol dIen 10mg
A phenol from cashew nut shell liquid; kills 50, 100, 100, and 100% of S. mansoni worms after 24 hours when used at concentrations of 25, 50, 100, or 200 µM, respectively; LC50 = 32.2 µM after 24 and 48 hours against S. mansoni worms; has been used as a starting material for the synthesis of bis-benzoxazines
Cayman Chemical D-threo-PPMPhydrochlorIde 10mg
A GlyCer synthetase inhibitor; an inhibitor of MDCK cell growth in vitro (70% reduction at 20 µM); an inhibitor of DNA synthesis at 3 µM
Cayman Chemical bk-2C-BhydrochlorIde 10mg
A β-ketone analog of 2C-B; intended for forensic and research purposes
Cayman Chemical 1 3 7TrImethylurIc AcIdd9 10mg
An internal standard for the quantification of 1,3,7-trimethyluric acid by GC- or LC-MS